Original
By certification 
Chemical Structure: MIK665
CAS No.: 1799631-75-6
MIK665(MIK 665, S 64315, S64315)
Catalog No.: URK-V595 Only Used For Lab.
MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.
Biological Activity
MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.
MIK665 (S-64315) binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1.
Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
Physicochemical Properties
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M.Wt |
875.413 |
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Formula |
C47H44ClFN6O6S |
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CAS No. |
1799631-75-6 |
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Storage |
Solide Powder -20 °C 3years; 4°C 2years |
In Solvent -80°C 6 Months -20°C 1 Months |
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Solubility |
10 mM in DMSO |
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Chemical Name |
(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid |
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References
1. Cassier PA, et al. Br J Cancer. 2017 Oct 10;117(8):1089-1098.
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